Independent roles for retinoic acid in segmentation and neuronal differentiation in the zebrafish hindbrain
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15 صفحه اولCellular retinoic acid-binding proteins are essential for hindbrain patterning and signal robustness in zebrafish.
The vitamin A derivative retinoic acid (RA) is a morphogen that patterns the anterior-posterior axis of the vertebrate hindbrain. Cellular retinoic acid-binding proteins (Crabps) transport RA within cells to both its nuclear receptors (RARs) and degrading enzymes (Cyp26s). However, mice lacking Crabps are viable, suggesting that Crabp functions are redundant with those of other fatty acid-bindi...
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Retinoic acid and Wnt/β-catenin signals play important roles during neuronal differentiation but less is known about noncanonical Wnt signals in this context. We examined retinoic acid and Wnt signaling in two human embryonal carcinoma cell lines, NTERA-2 (clone D1), which undergoes neuronal differentiation in response to retinoic acid, and 2102Ep, which does not. Retinoic acid treatment inhibi...
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In nearly all adult vertebrates, the vasculature is of key importance for supplying nutrients and oxygen to the brain. Throughout the nervous system, neurons and blood vessels align closely to form the neurovascular unit [1]. Little is known, however, about the causal role of the vasculature during the embryonic establishment of neuronal pathways and functional activity. In addition, little inf...
متن کاملRetinoic acid synthesis and hindbrain patterning in the mouse embryo.
Targeted disruption of the murine retinaldehyde dehydrogenase 2 (Raldh2) gene precludes embryonic retinoic acid (RA) synthesis, leading to midgestational lethality (Niederreither, K., Subbarayan, V., Dolle, P. and Chambon, P. (1999). Nature Genet. 21, 444-448). We describe here the effects of this RA deficiency on the development of the hindbrain and associated neural crest. Morphological segme...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2004
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2004.02.022